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KMID : 0363319980190010442
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Journal of Korean Oriental Internal Medicine
1998 Volume.19 No. 1 p.442 ~ p.451
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Underlying mechanism of antioxidant action of Holotrichia in renal tissues
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Jung Ji-Chun
Moon Sang-Won
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Abstract
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This study was carried out to examine mechanisms by which Holotrichia (HTC) produces protective effect against renal cell injury. HTC extraction (5%) prevented H₂O₂(50mM)-induced LDH release and lipid peroxidation in renal cortical slices. When slices were treated with 5% HTC extraction, cellular glutathione content and the superoxide dismutase activity were not altered in control and H₂O₂-treated tissues. When slices were treated with 50 mM H₂O₂, the catalase activity was significantly inhibited, which was completely restored by addition of 5% HTC. Treatment of slices with 5% HTC extraction increased the glutation peroxidase activity in H₂O₂-treated tissues. These results suggest that HTC prevents oxidant-induced cell injury and lipid peroxidation by increasing the activities of catalase and glutathione peroxidase in renal cortical slices.
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KEYWORD
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Holotrichia, LDH, lipid peroxidation, catalase, glutathione peroxidase
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